GLP-2R agonism
Published work characterises binding at the GLP-2 receptor and the cAMP/PKA signalling that follows in intestinal subepithelial cells, including cross-talk with IGF-1 and EGF receptor pathways.
≥99% Purity · HPLC 
Independently verified
PASS
- Lot
- RFX-2606-025
- Purity (HPLC)
- 99.4%
- Identity
- LC-MS confirmed
- Tested
- June 2026
- Analysed by
- Independent U.S. laboratory
These are results measured on this lot. Full material specification is in Know your compound.
GLP Compound
GLP-2 TZ
A DPP-IV-resistant GLP-2 analog studied in intestinal adaptation and mucosal biology research.
$260.00 $2.60/mg
$130.00 per vial with BOGO
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- Ships from the US
- Discreet packaging
- Free shipping $100+
Research use only — not for human or veterinary use, diagnostic or therapeutic.
33 Amino acids
3,752 g/mol
GLP-2R Receptor target
≥99% HPLC purity
Know your compound
What is GLP-2 TZ?
GLP-2 TZ is a synthetic analog of glucagon-like peptide-2, the 33-amino-acid hormone released by enteroendocrine L-cells in the distal intestine. Native GLP-2 is cleaved by dipeptidyl peptidase-IV at the second residue and survives roughly seven minutes in plasma — too short to study cleanly. The analog carries a single substitution at that position (alanine to glycine) which removes the cleavage site, and that one change is what makes the molecule usable as a laboratory research tool.
Despite the shared “GLP” name, this is not an incretin analog. It acts at the GLP-2 receptor — a Gs-coupled GPCR whose expression is unusually confined to the gut wall, appearing on intestinal subepithelial myofibroblasts, enteric neurons, and scattered enteroendocrine cells. That is a different receptor and a different literature from GLP-1 or GIP compounds, whose receptors are distributed across the pancreas, heart, brain, and kidney. Published research on this compound class sits in intestinal biology, not metabolic research.
Reflex supplies GLP-2 TZ as a lyophilized powder for laboratory research use only. Each lot is assayed by an independent U.S. laboratory and ships with its Certificate of Analysis. Nothing on this page describes an approved therapy or a use in humans; it summarises what published research has examined.
3D model
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Sequence
- 1 His
- 2 Gly
- 3 Asp
- 4 Gly
- 5 Ser
- 6 Phe
- 7 Ser
- 8 Asp
- 9 Glu
- 10 Met
- 11 Asn
- 12 Thr
- 13 Ile
- 14 Leu
- 15 Asp
- 16 Asn
- 17 Leu
- 18 Ala
- 19 Ala
- 20 Arg
- 21 Asp
- 22 Phe
- 23 Ile
- 24 Asn
- 25 Trp
- 26 Leu
- 27 Ile
- 28 Gln
- 29 Thr
- 30 Lys
- 31 Ile
- 32 Thr
- 33 Asp
- Hydrophobic
- Polar
- Acidic
- Basic
- Special
Read left to right from the N-terminus. Mass spectrometry checks each lot against this sequence — that result is the “Identity” line on the certificate.
Identity
What the molecule is.
- Amino acids
- 33
- How many residues make up the chain.
- Molecular formula
- C164H252N44O55
- The atom count in a single molecule.
- Molecular weight
- 3,752.13 g/mol
- The mass of one mole. You need this figure to calculate concentration when reconstituting.
- CAS
- 197922-42-2
- The registry number that identifies this substance unambiguously in chemical databases.
- Classification
- Synthetic GLP-2 receptor agonist peptide
- The research category this compound is grouped under.
Verification
How we know the material matches the label.
- Purity
- ≥99% (RP-HPLC, per lot)
- The share of the material that is the target compound, measured by reverse-phase HPLC on every lot — not a blanket brand claim.
- Identity method
- LC-MS confirmed
- Mass spectrometry compares the material against the expected sequence to confirm it is the right molecule.
- Documentation
- Certificate of Analysis, per lot
- The certificate for your specific lot is published before it ships and stays searchable by lot number.
Handling
What arrives, and how it is kept.
- Form
- Lyophilized powder
- The physical state the vial arrives in.
- Storage
- −20°C lyophilized, protected from light; 2–8°C once reconstituted, used within 30 days
- Conditions the material is kept under.
- Solubility
- Bacteriostatic water or sterile saline
- What the material dissolves in.
What the literature examines
Studied pathways
Summaries of what published research has investigated. Preclinical unless stated otherwise — not claims about this product.
Mucosal trophic signalling
Studies examine crypt cell proliferation and enterocyte apoptosis in villus epithelium — the two processes that together determine mucosal surface area in resection and injury models.
DPP-IV resistance
The substitution at position 2 blocks dipeptidyl peptidase-IV cleavage. Literature in this class compares the resulting exposure profile against native GLP-2 and its roughly seven-minute half-life.
Certificate of Analysis
Every vial ships with its own report
Not a brand-wide spec sheet — a lot-specific certificate from an independent laboratory, published before the lot ships and searchable by lot number forever.
- Lot-specific HPLC purity and LC-MS identity
- Raw chromatogram attached to the certificate
- Signed by the analysing laboratory
- Permanent public archive, searchable by lot ID
Independent U.S. laboratory
Certificate of Analysis · RFX-2606-025
| Test | Specification | Result |
|---|---|---|
| Purity (HPLC) | ≥ 99.0% | 99.4% |
| Identity (LC-MS) | Conforms | Conforms |
| Appearance | White powder | Conforms |
| Net content | Label claim | Conforms |
The research
What the published literature examines
Summaries of independent research on this compound class — findings from other people's published work, not claims about the material sold here.
Intestinal adaptation
The largest body of work uses small-bowel resection models, where GLP-2 receptor activation has been studied against villus height, crypt depth, and total mucosal surface area. The analog class is the standard research tool for intestinal adaptation after resection.
Epithelial barrier function
Published work examines paracellular permeability and tight-junction integrity in intestinal epithelium, measuring barrier function in injury models rather than a therapeutic endpoint.
Inflammatory bowel models
Rodent colitis and Crohn’s models have been used to study mucosal inflammation and epithelial healing under GLP-2 receptor signalling.
Questions
GLP-2 TZ FAQ
Is GLP-2 TZ approved by the FDA?
No. GLP-2 TZ is not an FDA-approved drug and is not approved for human or veterinary use. It is supplied exclusively as a research material for laboratory use, and it is not intended to diagnose, treat, cure, or prevent any disease.
Does this lot come with a Certificate of Analysis?
Yes. Every lot is assayed by an independent U.S. laboratory for purity and identity, and the certificate for the lot you receive is published in our COA library — you can read it before you order.
How is purity determined?
Purity is quantified by reverse-phase HPLC against a reference standard, and identity is confirmed by mass spectrometry. Both results appear on the lot certificate.
How should this be stored?
Lyophilized material is typically stored cold and protected from light. Handling and storage are the responsibility of the receiving laboratory; refer to the lot documentation for specifics.
How does the buy-one-get-one offer work?
Every second vial is free, sitewide and automatically. Add two vials and you pay for one; add six and you pay for three. Compounds can be mixed, there is no code, and there is no limit.
When will my order ship?
Orders are processed promptly and shipped with tracking. Free US shipping applies over $100; Priority shipping is $8.95 otherwise.
The guarantee
99.4% pure — or your money back.
Have any lot independently re-tested. If the results don't match the purity printed on its published certificate, we refund the order in full — no returns, no argument.
Test it yourselfSend any vial to a lab of your choosing.
Published firstThe certificate goes public before the lot ships.
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